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High-risk Patients for Colorectal Cancer Lack Colonoscopy Knowledge

High-risk patients with advanced colorectal polyps have a three-fold higher risk of developing colorectal cancer.

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Colorectal cancer is the third most common cause of cancer deaths in the United States and advanced colorectal polyps are a major risk factor. These high-risk patients have a three-fold higher risk of developing colorectal cancer and therefor a three-year follow up interval of colonoscopy is generally recommended. Many clinicians rely on self-reports from their high-risk patients about their need and proper interval for repeat surveillance colonoscopy.

In a study published in the , researchers from 91����’s analyzed data over a period of four years from 2013 to 2017 to explore the knowledge of these high-risk patients. They analyzed data from structured interviews on 84 subjects between ages 40 to 91 years old with biopsy proven advanced colorectal polyps.

Results showed that 28.6 percent were unaware of either the need for a repeat colonoscopy or the proper surveillance interval. Of these, 16.6 percent were unaware of the proper three-year interval to obtain a follow-up surveillance colonoscopy. In addition, 12 percent were not even aware that they required a follow-up surveillance colonoscopy.

Screening modalities for colorectal cancer include fecal immune testing, multi-targeted stool DNA testing, flexible sigmoidoscopy and colonoscopy.

“Our data demonstrate a lack of knowledge of patients with biopsy proven advanced colorectal polyps about their need for repeat colonoscopy as well as the proper surveillance interval,” said , M.D., co-author, a gastroenterologist and an affiliate associate professor in 91����’s Schmidt College of Medicine. “For patients with biopsy proven advanced colorectal polyps, the interval for colonoscopy is about three years. Our data raise a challenge for us to rely on more objective data than self-reports. Clinicians should have the ability and willingness to share their objective findings with all clinical colleagues involved in the care of the patient. These efforts should also include younger patients such as Chadwick Boseman who recently died of colon cancer at age 43.”  

The incidence of colorectal cancer is increasing in younger people. According to the American Cancer Society, from 2007 to 2016, incidence rates of colorectal cancer in people 55 years or older dropped by 3.6 percent each year, but increased by 2 percent each year in those younger than 55.   

“Data from our study pose clinical and public health challenges to reduce the rates of recurrences of colorectal polyps as well as subsequent risks of colorectal cancer in these high-risk patients,” said , M.D., Dr.P.H., senior author, first Sir Richard Doll Professor and senior academic advisor in 91����’s Schmidt College of Medicine. “More than 90 percent of patients diagnosed with colorectal cancer are 50 years or older. The major risk factors for colorectal cancer are similar to those for heart attacks and stroke and include overweight and obesity, type 2 diabetes, as well as physical inactivity.”   

The researchers say that if such strategies were adopted for all patients it would have major clinical and public health implications. Specifically, it also would avoid the overutilization of colonoscopies for lower risk patients and increase both the benefit-to-risk and benefit-to-cost ratio from a public health perspective.  

According to the U.S. Centers for Disease Control and Prevention, additional risk factors include inflammatory bowel disease such as Crohn’s disease or ulcerative colitis; a personal or family history of colorectal cancer or colorectal polyps; and a genetic syndrome such as familial adenomatous polyposis or hereditary non-polyposis colorectal cancer (Lynch syndrome).

Co-authors include Evin Rothschild, first author and a senior at ; Benjamin Fiedler, a second-year 91���� medical student; Michael DeDonno, Ph.D., an associate professor, 91����’s  College of Education; Kosi Anago, M.D., a former 91���� internal medicine resident; Leonie de la Cruz, a former 91���� medical student; and , M.D., an associate professor, 91����’s Schmidt College of Medicine.

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